This study presents the diagnosis, rationale, building blocks and recommendations for the forthcoming Mining Strategy of Well-being for the Region of Antofagasta 2023-2050 (hereafter the Mining Strategy). The OECD, together with the Catholic University of the North, Chile, supported the regional government of Antofagasta in the preparation of this medium- and long-term strategy that aims at promoting sustainability and prioritising the well-being standards of citizens living in Antofagasta.